The Membrane Composition Defines the Spatial Organization and Function of a Major Acinetobacter baumannii Drug Efflux System

Author:

Zang Maoge1,MacDermott-Opeskin Hugo2,Adams Felise G.1ORCID,Naidu Varsha3,Waters Jack K.1,Carey Ashley B.14,Ashenden Alex14,McLean Kimberley T.5,Brazel Erin B.5ORCID,Jiang Jhih-Hang6ORCID,Panizza Alessandra2,Trappetti Claudia5,Paton James C.5ORCID,Peleg Anton Y.67,Köper Ingo14ORCID,Paulsen Ian T.3ORCID,Hassan Karl A.8,O’Mara Megan L.2,Eijkelkamp Bart A.1ORCID

Affiliation:

1. Molecular Sciences and Technology, College of Science and Engineering, Flinders University, Adelaide, South Australia, Australia

2. Research School of Chemistry, College of Science, The Australian National University, Canberra, Australian Capital Territory, Australia

3. Department of Molecular Sciences, Macquarie University, Sydney, New South Wales, Australia

4. Flinders Centre for Nanoscale Science and Technology, Flinders University, Adelaide, South Australia, Australia

5. Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia

6. Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria, Australia

7. Department of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, Australia

8. School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales, Australia

Abstract

Antimicrobial resistance is an emerging global health crisis. Consequently, we have a critical need to prolong our current arsenal of antibiotics, in addition to the development of novel treatment options.

Funder

Department of Health, Australian Government | National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Reference16 articles.

1. CDC. 2019. Antibiotic resistance threats in the United States. Centers for Disease Control and Prevention, Atlanta, GA.

2. WHO. 2017. WHO publishes list of bacteria for which new antibiotics are urgently needed. https://www.who.int/news/item/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed.

3. Exogenous polyunsaturated fatty acids (PUFAs) alter phospholipid composition, membrane permeability, biofilm formation and motility in Acinetobacter baumannii

4. Identification of Novel Acinetobacter baumannii Host Fatty Acid Stress Adaptation Strategies

5. Docosahexaenoic Acid

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