Affiliation:
1. Department of Biochemistry, University of Missouri—Columbia, Columbia, Missouri 65211
Abstract
ABSTRACT
When tethered in
cis
to DNA, the transcriptional corepressor mSin3B inhibits polyomavirus (Py)
ori
-dependent DNA replication in vivo. Histone deacetylases (HDACs) appear not to be involved, since tethering class I and class II HDACs in
cis
does not inhibit replication and treating the cells with trichostatin A does not specifically relieve inhibition by mSin3B. However, the mSin3B L59P mutation that impairs mSin3B interaction with N-CoR/SMRT abrogates inhibition of replication, suggesting the involvement of N-CoR/SMRT. Py large T antigen interacts with mSin3B, suggesting an HDAC-independent mechanism by which mSin3B inhibits DNA replication.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Cited by
3 articles.
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