Distribution of Azithromycin in Plasma and Tonsil Tissue after Repeated Oral Administration of 10 or 20 Milligrams per Kilogram in Pediatric Patients-Reference-Cited by-同舟云学术

Distribution of Azithromycin in Plasma and Tonsil Tissue after Repeated Oral Administration of 10 or 20 Milligrams per Kilogram in Pediatric Patients

Published:2002-05 Issue:5 Volume:46 Page:1594-1596
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Blandizzi Corrado¹,Malizia Tecla²,Batoni Giovanna²,Ghelardi Emilia²,Baschiera Fabio¹,Bruschini Paolo³,Senesi Sonia²,Campa Mario²,Del Tacca Mario¹

Affiliation:

1. Division of Pharmacology and Chemotherapy, Department of Oncology, Transplants and Advanced Technologies in Medicine

2. Section of Microbiology, Department of Experimental Pathology, Medical Biotechnologies, Infectious Diseases and Epidemiology

3. Division of Otorhinolaryngology, University Hospital of Pisa, Pisa, Italy

Abstract

ABSTRACT Azithromycin concentrations in the tonsils of 56 pediatric patients, treated with 10 or 20 mg of the drug per kg of body weight for 3 days, were compared. Azithromycin levels in plasma and tonsil samples were determined up to 8.5 days after the last dose. The 20-mg/kg regimen resulted in an improved tonsillar distribution of azithromycin, suggesting the achievement of enhanced therapeutic concentrations at infective sites of the upper respiratory tract.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.46.5.1594-1596.2002

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