Increase in Quinolone Resistance in a Haemophilus influenzae Strain Isolated from a Patient with Recurrent Respiratory Infections Treated with Ofloxacin-Reference-Cited by-同舟云学术

Increase in Quinolone Resistance in a Haemophilus influenzae Strain Isolated from a Patient with Recurrent Respiratory Infections Treated with Ofloxacin

Published:1999-01 Issue:1 Volume:43 Page:161-162
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Vila Jordi¹,Ruiz Joaquim¹,Sanchez Ferran²,Navarro Ferran²,Mirelis Beatriz²,de Anta M. Teresa Jimenez¹,Prats Guillem²

Affiliation:

1. Departament de Microbiologia, Institut de Investigació Biomédica August Pi i Sunyer, Hospital Clı́nic, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona,1 and

2. Departament de Genètica i Microbiologia, Universitat Autonoma de Barcelona, Hospital de Sant Pau, 08025 Barcelona,2 Spain

Abstract

ABSTRACT The increase in the level of quinolone resistance of Haemophilus influenzae clinical isolates during ofloxacin therapy of a patient with recurrent respiratory infections was investigated. The first isolate (MIC of ciprofloxacin of 2 μg/ml) and the second isolate (MIC of 32 μg/ml) belonged to the same clone, as shown by pulsed-field gel electrophoresis, and the increase in the resistance level was associated with a substitution in Ser-84 to Arg in the ParC protein. These results emphasize the potential risk of development of quinolone-resistant H. influenzae during fluoroquinolone therapy in patients with recurrent respiratory infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.1.161

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