Affiliation:
1. Department of Microbiology, Monash University, Clayton, Victoria 3168, Australia
Abstract
ABSTRACT
The
ponA
gene of
Mycobacterium smegmatis
encodes a 95-kDa penicillin binding protein, PBP1, that is similar to PBP1s of
Mycobacterium tuberculosis
and
Mycobacterium leprae
. Transposon disruption of
ponA
in
M. smegmatis
resulted in a PBP1-deficient mutant that was sensitive to β-lactam antibiotics, was more permeable to glycine, and grew slowly in liquid culture.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
28 articles.
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