Genetic Variation/Evolution and Differential Host Responses Resulting from In-Patient Adaptation of Mycobacterium avium-Reference-Cited by-同舟云学术

Genetic Variation/Evolution and Differential Host Responses Resulting from In-Patient Adaptation of Mycobacterium avium

Published:2019-04 Issue:4 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Kannan N.¹²^ORCID,Lai Y.-P.³,Haug M.¹²⁴,Lilleness M. K.¹²,Bakke S. S.¹²,Marstad A.¹²,Hov H.²⁵,Naustdal T.⁶,Afset J. E.²⁷,Ioerger T. R.³,Flo T. H.¹²,Steigedal M.¹²⁷

Affiliation:

1. Centre of Molecular Inflammation Research (CEMIR), Norwegian University of Science and Technology (NTNU), Trondheim, Norway

2. Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

3. Department of Computer Science and Engineering, Texas A&M University, College Station, Texas, USA

4. Department of Infection, St. Olavs University Hospital, Trondheim, Norway

5. Department of Pathology, St. Olavs University Hospital, Trondheim, Norway

6. Levanger Hospital, Health Trust Nord-Trøndelag, Department of Internal Medicine, Levanger, Norway

7. Department of Medical Microbiology, St. Olavs University Hospital, Trondheim, Norway

Abstract

Members of the Mycobacterium avium complex (MAC) are characterized as nontuberculosis mycobacteria and are pathogenic mainly in immunocompromised individuals. MAC strains show a wide genetic variability, and there is growing evidence suggesting that genetic differences may contribute to a varied immune response that may impact the infection outcome.

Funder

Research Council of Norway

Helse Midt-Norge

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00323-18

Reference65 articles.

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2. Surrounded by mycobacteria: nontuberculous mycobacteria in the human environment