RNA-Binding Proteins PCBP1 and PCBP2 Are Critical Determinants of Murine Erythropoiesis-Reference-Cited by-同舟云学术

RNA-Binding Proteins PCBP1 and PCBP2 Are Critical Determinants of Murine Erythropoiesis

Published:2021-08-24 Issue:9 Volume:41 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Ji Xinjun¹^ORCID,Jha Anupama²,Humenik Jesse¹,Ghanem Louis R.³,Kromer Andrew¹,Duncan-Lewis Christopher¹,Traxler Elizabeth⁴,Weiss Mitchell J.⁵,Barash Yoseph¹,Liebhaber Stephen A.¹⁶

Affiliation:

1. Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA

2. Department of Computer and Information Science, School of Engineering and Applied Science at the University of Pennsylvania, Philadelphia, Pennsylvania, USA

3. Gastroenterology, Hepatology and Nutrition Division, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

4. Cell and Molecular Biology Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA

5. Department of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA

6. Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA

Abstract

We previously demonstrated that the two paralogous RNA-binding proteins PCBP1 and PCBP2 are individually essential for mouse development: Pcbp1 -null embryos are peri-implantation lethal, while Pcbp2 -null embryos lose viability at midgestation. Midgestation Pcbp2 −/− embryos revealed a complex phenotype that included loss of certain hematopoietic determinants. Whether PCBP2 directly contributes to erythropoietic differentiation and whether PCBP1 has a role in this process remained undetermined.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00668-20

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