Development and Validation of a Phenotypic High-Content Imaging Assay for Assessing the Antiviral Activity of Small-Molecule Inhibitors Targeting Zika Virus

Author:

Bernatchez Jean A.12,Yang Zunhua3,Coste Michael4,Li Jerry3,Beck Sungjun1,Liu Yan3,Clark Alex E.15,Zhu Zhe67ORCID,Luna Lucas A.4,Sohl Christal D.4,Purse Byron W.4,Li Rongshi3,Siqueira-Neto Jair L.12

Affiliation:

1. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA

2. Center for Discovery and Innovation in Parasitic Diseases, University of California, San Diego, La Jolla, California, USA

3. Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska, USA

4. Department of Chemistry and Biochemistry, San Diego State University, San Diego, California, USA

5. Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, USA

6. Sanford Consortium for Regenerative Medicine, La Jolla, California, USA

7. Department of Medicine, Division of Regenerative Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA

Abstract

Zika virus (ZIKV) has been linked to the development of microcephaly in newborns, as well as Guillain-Barré syndrome. There are currently no drugs available to treat ZIKV infection, and accordingly, there is an unmet medical need for the discovery of new therapies.

Funder

Nebraska Research Initiative

CTRI Pilot Grant

University of Nebraska Medical Center

San Diego State University

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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