Abstract
The nucleotide sequence was determined for the hemagglutinin gene of the Hong Kong subtype influenza strain A/Bangkok/1/79. The amino acid sequence predicted from these data shows a total of 36 amino acid changes as compared with hemagglutinin for a 1968 Hong Kong strain, 11 more than had occurred in a 1975 strain. The distribution of these changes confirmed that there are conserved and highly variable regions in hemagglutinin as the viral gene evolves during antigenic drift in the Hong Kong subtype. Of the four variable regions found in this study, only two have been seen previously. Correlation of highly variable areas in the hemagglutinins of Hong Kong subtype field strains with sites of amino acid changes in antigenically distinct influenza variants enabled us to predict likely antigenic regions of the protein. The results support and extend similar predictions made recently, based on the three-dimensional arrangement of hemagglutinin from a 1968 influenza strain.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Reference39 articles.
1. Atassi M. Z. 1977. The complete structure of myoglobin: approaches and conclusions for antigenic structures of proteins Article title p . 77-176. In M. Z. Atassi (ed.) Immunochemistry of proteins vol. 2. Plenum Publishing Corp. New York.
2. Precise determination of the entire antigenic structure of Iysozyme;Atassi M. Z.;Immunochemistry,1978
3. Nucleotide sequence coding for the N-terminal region of the matrix protein of influenza virus;Both G. W.;Eur. J. Biochem.,1979
4. Complete nucleotide sequence of the haemagglutinin gene from a human influenza virus of the Hong Kong subtype;Both G. W.;Nucleic Acids Res.,1980
5. Both G. W. M. J. Sleigh V. J. Bender and B. A. Moss. 1980. A comparison of antigenic variation in Hong Kong influenza virus haemagglutinins at the nucleic acid level p. 81-89. In W. G. Laver and G. M. Air (ed.) Structure and variation in influenza virus. Elsevier/North-Holland Publishing Co. New York.
Cited by
87 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献