Loureirin A is a narrow-spectrum antimicrobial agent against Helicobacter pylori

Author:

Tong Qian12,Yin Chengqiang123,Hang Xudong12,Bai Yuefan12,Zhang Chongwen12,Xu Jingcheng12,Huang Yan12,Ge Yixin12,Chen Tianyu12,Zeng Liping12,Jia Jia12,Bi Hongkai12ORCID

Affiliation:

1. Department of Pathogen Biology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, China

2. Helicobacter pylori Research Center, Nanjing Medical University, Nanjing, China

3. Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China

Abstract

ABSTRACT Currently, Helicobacter pylori eradication by antibiotic therapy faces various challenges, including antibiotic resistance, side effects on intestinal commensal bacteria, and patient compliance. In this study, loureirin A (LrA), a traditional Chinese medicine monomer extracted from Sanguis Draconis flavones, was found to possess specific antibacterial activity against H. pylori without the bacteria displaying a tendency to develop resistance in vitro . LrA demonstrated a synergistic or additive effect when combined with omeprazole (a proton pump inhibitor) against H. pylori . The combination of LrA and omeprazole showed promising anti- H . pylori potential, exhibiting notable in vivo efficacy comparable to standard triple therapy in mouse models infected with both drug-sensitive and drug-resistant H. pylori strains. Moreover, the narrow-spectrum antibacterial profile of LrA is reflected in its minimal effect on the diversity and composition of the mouse gut microbiota. The underlying mechanism of action of LrA against H. pylori involves the generation of bactericidal levels of reactive oxygen species, resulting in apoptosis-like cell death. These findings indicate that LrA is a promising lead compound targeting H. pylori without harming the commensal bacteria.

Funder

MOST | National Natural Science Foundation of China

MOST | National Key Research and Development Program of China

Publisher

American Society for Microbiology

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