High Rate of Reduced Susceptibility to Ciprofloxacin and Ceftriaxone among Nontyphoid Salmonella Clinical Isolates in Asia

Author:

Lee Hao-Yuan12,Su Lin-Hui12,Tsai Ming-Han12,Kim Shin-Woo3,Chang Hyun-Ha3,Jung Sook-In4,Park Kyung-Hwa4,Perera Jennifer5,Carlos Celia6,Tan Ban Hock7,Kumarasinghe Gamini7,So Thomas8,Chongthaleong Anan9,Hsueh Po-Ren10,Liu Jien-Wei11,Song Jae-Hoon12,Chiu Cheng-Hsun12

Affiliation:

1. Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan

2. Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan

3. Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea

4. Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea

5. University of Colombo, Colombo, Sri Lanka

6. Research Institute for Tropical Medicine, Manila, Philippines

7. Singapore General Hospital, National University of Singapore, Singapore

8. Princess Margaret Hospital, Hong Kong

9. Chulalongkorn University, Bangkok, Thailand

10. Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan

11. Chang Gung Memorial Hospital, Kaohsiung, Taiwan

12. Samsung Medical Center, Seoul, Korea

Abstract

ABSTRACT This multinational study from Asia revealed that reduced susceptibility to ciprofloxacin (MIC, 0.125 to 1 μg/ml) in nontyphoid Salmonella isolates was common in Taiwan (48.1%) and Thailand (46.2%) and in S. enterica serotype Choleraesuis (68.8%) and S . Virchow (75.0%) from all countries. Reduced susceptibility to ceftriaxone (MIC, 2 to 8 μg/ml) remained uncommon in Asia, except in Taiwan (38.0%) or in S . Typhimurium (25.0%) from all countries.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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