Metronidazole Metabolism in Cultures of Entamoeba histolytica and Trichomonas vaginalis-Reference-Cited by-同舟云学术

Metronidazole Metabolism in Cultures of Entamoeba histolytica and Trichomonas vaginalis

Published:1981-09 Issue:3 Volume:20 Page:410-414
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Beaulieu Bernard B.¹,McLafferty Martha A.¹,Koch Ronald L.¹,Goldman Peter²

Affiliation:

1. Charles A. Dana Research Institute and the Harvard Thorndike Laboratory of Beth Israel Hospital, Department of Medicine, Beth Israel Hospital, Boston, Massachusetts 02215

2. Division of Clinical Pharmacology, Department of Pharmacology, Harvard Medical School, Boston, Massachusetts 02115

Abstract

Acetamide forms from metronidazole in cultures of either Entamoeba histolytica or Trichomonas vaginalis as it does in cultures of bacteria which are susceptible to this drug. Under aerobic conditions, the formation of acetamide is more rapid in a strain of T. vaginalis which is more susceptible to metronidazole. Thus, it appears that the formation of acetamide may be associated with the microbiocidal action of metronidazole.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.20.3.410

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