Broadly Reactive IgG Responses to Heterologous H5 Prime-Boost Influenza Vaccination Are Shaped by Antigenic Relatedness to Priming Strains-Reference-Cited by-同舟云学术

Broadly Reactive IgG Responses to Heterologous H5 Prime-Boost Influenza Vaccination Are Shaped by Antigenic Relatedness to Priming Strains

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Wang Jiong¹,Li Dongmei²,Perry Sheldon¹,Hilchey Shannon P.¹,Wiltse Alexander¹,Treanor John J.³,Sangster Mark Y.⁴,Zand Martin S.¹²⁵^ORCID

Affiliation:

1. Department of Medicine, Division of Nephrology, University of Rochester Medical Center, Rochester, New York, USA

2. Informatics Core, Clinical, and Translational Science Institute, University of Rochester, Rochester, New York, USA

3. Department of Medicine, Division of Infectious Diseases, University of Rochester Medical Center, Rochester, New York, USA

4. Department of Immunology, Vaccine Center, University of Rochester Medical Center, Rochester, New York, USA

5. Rochester Center for Health Informatics, University of Rochester Medical Center, Rochester, New York, USA

Abstract

The antigenic shift and draft of hemagglutinin (HA) in influenza viruses is accepted as one of the major reasons for immune evasion. The analysis of B cell immune responses to influenza infection and vaccination is complicated by the impact of exposure history and antibody cross-reactions between antigenically similar influenza strains.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

HHS | NIH | National Center for Advancing Translational Sciences

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00449-21

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