CD40 in Endothelial Cells Restricts Neural Tissue Invasion by Toxoplasma gondii-Reference-Cited by-同舟云学术

CD40 in Endothelial Cells Restricts Neural Tissue Invasion by Toxoplasma gondii

Published:2019-08 Issue:8 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Portillo Jose-Andres C.¹,Van Grol Jennifer¹²,Saffo Saad¹,Lopez Corcino Yalitza¹²,Rodriguez Myriam¹,Fox Barbara A.³,Bzik David J.³,Ward Nicole L.⁴,Dubyak George R.⁵,Rojas Roxana E.¹,Toosi Zahra¹⁶,Subauste Carlos S.¹²

Affiliation:

1. Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

2. Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

3. Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA

4. Department of Dermatology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

5. Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

6. Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio, USA

Abstract

Little is known about whether pathogen invasion of neural tissue is affected by immune-based mechanisms in endothelial cells. We examined the effects of endothelial cell CD40 on Toxoplasma gondii invasion of the retina and brain, organs seeded hematogenously. T. gondii circulates in the bloodstream within infected leukocytes (including monocytes and dendritic cells) and as extracellular tachyzoites.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00868-18

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3. CD40 AND CD154 IN CELL-MEDIATED IMMUNITY