Detection of Hepatitis B Virus (HBV) Genotype E Carried—Even in the Presence of High Titers of Anti-HBs Antibodies—by an Argentinean Patient of African Descent Who Had Received Vaccination against HBV-Reference-Cited by-同舟云学术

Detection of Hepatitis B Virus (HBV) Genotype E Carried—Even in the Presence of High Titers of Anti-HBs Antibodies—by an Argentinean Patient of African Descent Who Had Received Vaccination against HBV

Published:2006-09 Issue:9 Volume:44 Page:3435-3439
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Mathet Verónica L.¹,Cuestas María L.¹,Ruiz Vanesa¹,Minassian María L.¹,Rivero Cintia¹,Trinks Julieta¹,Daleoso Graciela²,León Liliana M.²,Sala Andrea³,Libellara Beatriz⁴,Corach Daniel³,Oubiña José R.¹

Affiliation:

1. Centro para el Estudio de Hepatitis Virales, Departamento de Microbiología, Facultad de Medicina, Universidad de Buenos Aires

2. Hospital Ramos Mejía

3. Laboratorio de Huellas Digitales y Cátedra de Genética Molecular, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires

4. Laboratorio de Biología Molecular, Hospital Italiano, Buenos Aires, Argentina

Abstract

ABSTRACT Genotype E hepatitis B virus (HBV) was detected in two Argentine sisters exhibiting an African mitochondrial lineage. One of them (who had been vaccinated against HBV) exhibited anti-HBs cocirculating antibodies without HBsAg escape mutants, while her unvaccinated sister showed a D144A HBsAg escape mutant without anti-HBs antibodies. Both sisters carried an unusual L209V substitution within HBsAg.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00866-06

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