Affiliation:
1. Experimental Therapy Division, Abbott Laboratories, North Chicago, Illinois 60064
Abstract
Two hundred eighty-five fungi, including 100 basidiomycetes and 35 yeasts, 75 actinomycetes, and 40 bacteria were screened for their ability to convert 5-anilino-1,2,3,4-thiatriazole (AT) to 5-(
p
-hydroxyanilino)-1,2,3,4-thiatriazole (
p
-HT). Eleven cultures were found that formed
p
-HT, which was isolated and whose structure was determined.
Aspergillus tamarii
NRRL 3280 formed 8.6 g of
p
-HT/liter from 10 g of AT/liter (78.9% conversion) in shaken flasks and 4.57 g of
p
-HT/liter from 6 g of AT/liter (69.8% conversion) in 30-liter fermentors. Washed cells of
A. tamarii
NRRL 3280 also carried out this conversion. 5-(
o
-hydroxyanilino)-1,2,3,4-thiatriazole (
o
-HT) was identified as a second product formed by
Aspergillus terreus
NRRL 1960.
Publisher
American Society for Microbiology
Subject
General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
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