Affiliation:
1. Laboratory of Enteric Infections, Department of Microbiology, National Institute of Health Korea
2. Graduate School of Biotechnology, Korea University, Seoul, Republic of Korea
Abstract
ABSTRACT
A nationwide survey was carried out in Korea to assess the prevalence of
Shigella
strains producing extended-spectrum β-lactamases (ESBLs). From 1991 to 2002, 5,911 clinical strains were isolated and screened for resistance to extended-spectrum cephalosporins. Twenty of the
Shigella
isolates were ESBL positive, based on the synergistic effects between clavulanate and selected β-lactams (ceftazidime and cefotaxime). Nucleotide sequence analysis of these isolates revealed that they harbored
bla
TEM-19
(eight isolates),
bla
TEM-15
(five isolates),
bla
TEM-52
(six isolates),
bla
TEM-17
(one isolate),
bla
TEM-20
(one isolate), and
bla
CTX-M-14
(three isolates). All the ESBL-encoding genes in this study were carried in conjugable plasmids. Thus, TEM-19, TEM-15, TEM-52, and CTX-M-14 β-lactamases can be considered common Korean ESBL types in
Shigella sonnei
and are probably transmitted through interspecies spread between medical facilities and the community in Korea. This is the first report of the presence of TEM-17, TEM-19, and TEM-20 in Korea and in
S. sonnei
.
Publisher
American Society for Microbiology
Cited by
60 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献