Engineering Oncolytic Coxsackievirus A21 with Small Transgenes and Enabling Cell-Mediated Virus Delivery by Integrating Viral cDNA into the Genome-Reference-Cited by-同舟云学术

Engineering Oncolytic Coxsackievirus A21 with Small Transgenes and Enabling Cell-Mediated Virus Delivery by Integrating Viral cDNA into the Genome

Published:2023-05-31 Issue:5 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Sam Miranda¹,Selman Mohammed²,Zhao Weilong³,Jung Jiwon¹,Willingham Aarron¹,Phan Uyen²,Starling Gary C.¹,Gao Qinshan¹^ORCID

Affiliation:

1. Discovery Biologics, Merck & Co., Inc., South San Francisco, California, USA

2. Discovery Oncology, Merck & Co., Inc., South San Francisco, California, USA

3. Scientific Informatics, Merck & Co., Inc., West Point, Pennsylvania, USA

Abstract

As a naturally occurring virus, coxsackievirus A21 is a promising oncolytic virotherapy modality. In this study, we first used reverse genetics to determine whether A21 can stably carry transgenes and found that it could express up to 141 amino acids of foreign GFP.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00309-23

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