In Vitro Antimicrobial Susceptibility of Anaerobic Bacteria Isolated from Clinical Specimens

Author:

Martin William J.1,Gardner Mildred1,Washington John A.1

Affiliation:

1. Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901

Abstract

The minimal inhibitory concentrations of 601 clinical isolates of anaerobic bacteria to 10 different antimicrobial agents were determined by an agar-dilution technique. Nearly all strains were resistant to kanamycin and gentamicin, although moderate activity to both drugs was noted with Fusobacterium sp., anaerobic cocci, some strains of Bacteroides melaninogenicus , and nonsporeforming gram-positive bacilli. Chloramphenicol at 12.5 μg/ml inhibited all but three of the strains tested. Tetracycline at 6.25 μg/ml had high activity against all groups tested, with the exception that only 39% of strains of Bacteroides fragilis were inhibited at this concentration. Excluding certain species of Bacteroides , the majority of anaerobes were inhibited by penicillin at 3.1 μg/ml or less and by cephalothin at 12.5 μg/ml or less. Lincomycin at 6.2 μg/ml or less was active against nearly all strains. Erythromycin at a concentration of 3.1 μg/ml was active against B. fragilis ; however, erythromycin was less active against the other groups. Most of the minimal inhibitory concentrations of lincomycin exceeded those of clindamycin by fourfold. Rifampin inhibited virtually all strains at 3.1 μg/ml.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference20 articles.

1. Bacteremic bacteroides infections;Bodner S. J.;Ann. Intern. Med.,1970

2. Dowell V. R. Jr. and T. M. Hawkins. 1968. Laboratory methods in anaerobic bacteriology. Center for Disease Control Atlanta.

3. Antibiotic sensitivity testing: report of an international collaborative study. Acta;Ericsson H. M.;Pathol. Microbiol. Scand. B Suppl.,1971

4. Comparative effect of broad-spectrum antibiotics on nonsporeforming anaerobes and normal bowel flora;Finegold S. M.;Ann. N. Y. Acad. Sci.,1967

5. Lincomycin: activity against anaerobes and effect on normal human fecal flora;Finegold S. M.;Antimicrob. Ag. Chemother.,1966

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