KPC-39-Mediated Resistance to Ceftazidime-Avibactam in a Klebsiella pneumoniae ST307 Clinical Isolate-Reference-Cited by-同舟云学术

KPC-39-Mediated Resistance to Ceftazidime-Avibactam in a Klebsiella pneumoniae ST307 Clinical Isolate

Published:2021-11-17 Issue:12 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Jousset Agnès B.¹²³⁴,Oueslati Saoussen¹³,Emeraud Cécile¹²³⁴,Bonnin Rémy A.¹²³^ORCID,Dortet Laurent¹²³⁴^ORCID,Iorga Bogdan I.⁵,Naas Thierry¹²³⁴^ORCID

Affiliation:

1. Team Resist, UMR1184, Immunology of Viral, Auto-Immune, Hematological, and Bacterial Diseases, INSERM, Université Paris-Saclay, CEA, LabEx LERMIT, Faculty of Medicine, Le Kremlin-Bicêtre, France

2. Associated French National Reference Center for Antibiotic Resistance: Carbapenemase-Producing Enterobacteriaceae, Le Kremlin-Bicêtre, France

3. Evolution and Ecology of Resistance to Antibiotics Unit, Institut Pasteur, AP-HP, Université Paris-Saclay, Paris, France

4. Bacteriology-Hygiene Unit, AP-HP, Université Paris-Saclay, Bicêtre Hospital, Le Kremlin-Bicêtre, France

5. Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, France

Abstract

Resistance to the ceftazidime (CAZ)-avibactam (AVI) combination is increasingly being reported. Here, we report a CAZ-AVI-resistant Klebsiella pneumoniae strain belonging to the high-risk sequence type 307 (ST307) clone and producing Klebsiella pneumoniae carbapenemase 39 (KPC-39), a single-amino-acid variant of KPC-3 (A172T).

Funder

Université Paris-Saclay

Assistance Publique - Hôpitaux de Paris

Agence Nationale de la Recherche

Institut National de la Santé et de la Recherche Médicale

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01160-21

Reference30 articles.