Pharmacokinetics, Tissue Distribution, and Efficacy of VIO-001 (Meropenem/Piperacillin/Tazobactam) for Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia in Immunocompetent Rabbits with Chronic Indwelling Vascular Catheters-Reference-Cited by-同舟云学术

Pharmacokinetics, Tissue Distribution, and Efficacy of VIO-001 (Meropenem/Piperacillin/Tazobactam) for Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia in Immunocompetent Rabbits with Chronic Indwelling Vascular Catheters

Published:2021-10-18 Issue:11 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Petraitis Vidmantas¹^ORCID,Petraitiene Ruta¹^ORCID,Kavaliauskas Povilas¹,Naing Ethan¹,Garcia Andrew¹,Sutherland Christina²,Kau Aki Yoneda³,Goldner Nicholas³,Bulow Christopher³,Nicolau David P.²^ORCID,Walsh Thomas J.¹⁴⁵

Affiliation:

1. Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine of Cornell University, New York, New York, USA

2. Center for Anti-Infective Research and Development at Hartford Hospital, Hartford, Connecticut, USA

3. Viosera Therapeutics, Brentwood, Missouri, USA

4. Department of Pediatrics, Weill Cornell Medicine of Cornell University, New York, New York, USA

5. Department of Microbiology and Immunology, Weill Cornell Medicine of Cornell University, New York, New York, USA

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) infections of surgically implanted subcutaneous vascular catheters (SISVCs) cause serious morbidity in patients with chronic illnesses. Previous in vitro and murine models demonstrated the synergistic interaction of equimolar concentrations of meropenem/piperacillin/tazobactam (MPT) (VIO-001) against MRSA infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01168-21

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