Biologic Activities of the TolC-Like Protein of Neisseria meningitidis as Assessed by Functional Complementation in Escherichia coli-Reference-Cited by-同舟云学术

Biologic Activities of the TolC-Like Protein of Neisseria meningitidis as Assessed by Functional Complementation in Escherichia coli

Published:2010-01 Issue:1 Volume:54 Page:506-508
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kamal Nazia¹,Shafer William M.¹²

Affiliation:

1. Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322

2. Laboratory of Bacterial Pathogenesis and Antimicrobial Resistance, VA Medical Center, Decatur, Georgia 30033

Abstract

ABSTRACT Neisseria meningitidis can produce a TolC-like protein needed for secretion of FrpC but not efflux of antimicrobials. We now report that expression of the meningococcal tolC gene in a TolC-deficient strain of Escherichia coli can restore properties of α-hemolysis and antimicrobial resistance known to involve efflux pumps.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01168-09

Reference29 articles.

1. Antibiotic-Sensitive TolC Mutants and Their Suppressors

2. A DEFINED AGAR MEDIUM FOR GENETIC TRANSFORMATION OF NEISSERIA MENINGITIDIS

3. Delahay, R. M., B. D. Robertson, J. T. Balthazar, W. M. Shafer, and C. A. Ison. 1997. Involvement of the gonococcal MtrE protein in the resistance of Neisseria gonorrhoeae to toxic hydrophobic agents. Microbiology143:2127-2133.

4. Neisseria meningitidis RTX Proteins Are Not Required for Virulence in Infant Rats

5. Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli

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