Comparison of moxalactam (LY127935) and cefotaxime against anaerobic bacteria

Author:

Jorgensen J H,Crawford S A,Alexander G A

Abstract

The in vitro activities of moxalactam (LY127935 [6059S]) and cefotaxime were compared with those of cefoxitin, cefamandole, cefuroxime, carbenicillin, and penicillin by agar dilution susceptibility testing of a variety of anaerobic bacteria. Moxalactam proved to be the most active agent tested against Bacteroides fragilis and other species of the B. fragilis group. Moxalactam and cefotaxime showed activity similar to the other drugs against the remaining species of Bacteroides, Fusobacterium, Actinomyces, Propionibacterium, and Veillonella. Penicillin was the most effective drug tested against most species of Clostridium, the anaerobic gram-positive cocci, and Eubacterium lentum.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Cited by 33 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. THE IN VITRO ACTIVITY OF MOXALACTAM AGAINST 430 CLINICAL, BACTERIAL ISOLATES;Acta Pathologica Microbiologica Scandinavica Series B: Microbiology;2009-08-15

2. Effectiveness of cefotaxime alone and in combination with desacetylcefotaxime against Bacteroides fragilis;Diagnostic Microbiology and Infectious Disease;1989-01

3. Management of Anaerobic Infections;Veterinary Clinics of North America: Small Animal Practice;1988-11

4. Cefuroxime Axetil;Drug Intelligence & Clinical Pharmacy;1988-09

5. Electron transfer mechanism for β-lactam antibiotic action via side-chain imine;Bioorganic Chemistry;1988-06

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