Affiliation:
1. Department of Medical Chemistry, and Department of Clinical Pathology, Osaka Medical College, Takatsuki City, Osaka, Japan
Abstract
We have extended our investigation of nicotinamide deamidation in the stomach of conventional rats. The bacterial species in the pars preventricularis were identified as
Flavobacterium peregrinum, Escherichia coli, Streptococcus faecalis
, and
Lactobacillus acidophilus
, listed in order of decreasing deamidase activity. Nicotinamide-
7
-
14
C
ingested into rat stomach was rapidly deamidated to nicotinic acid. These results contribute to the accumulated evidence that microorganisms present in the pars preventricularis of rat stomach are responsible for the deamidation of nicotinamide to nicotinic acid, a known precursor of mammalian pyridine nucleotides.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
10 articles.
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