Coronavirus Porcine Epidemic Diarrhea Virus Nucleocapsid Protein Interacts with p53 To Induce Cell Cycle Arrest in S-Phase and Promotes Viral Replication

Author:

Su Mingjun1,Shi Da2,Xing Xiaoxu1,Qi Shanshan1,Yang Dan1,Zhang Jiyu2,Han Yuru2,Zhu Qinghe1,Sun Haibo1,Wang Xiaoran1,Wu Haoyang1,Wang Meijiao1,Wei Shan1,Li Chunqiu1,Guo Donghua1,Feng Li2,Sun Dongbo1ORCID

Affiliation:

1. College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Sartu District, Daqing, China

2. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

Abstract

Many viruses subvert the host cell cycle to create a cellular environment that promotes viral growth. PEDV, an emerging and reemerging coronavirus, has led to substantial economic loss in the global swine industry.

Funder

Heilongjiang Bayi Agricultural University Support Program for San Heng San Zong

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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