Systematic Therapeutic Drug Monitoring for Linezolid: Variability and Clinical Impact-Reference-Cited by-同舟云学术

Systematic Therapeutic Drug Monitoring for Linezolid: Variability and Clinical Impact

Published:2017-10 Issue:10 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Galar Alicia¹²^ORCID,Valerio Maricela¹²,Muñoz Patricia¹²³⁴,Alcalá Luis¹²⁴,García-González Xandra²⁵,Burillo Almudena¹²³,Sanjurjo María²⁵,Grau Santiago⁶⁷,Bouza Emilio¹²³⁴

Affiliation:

1. Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain

2. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain

3. Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain

4. CIBER Enfermedades Respiratorias-CIBERES (CB06/06/0058), Madrid, Spain

5. Pharmacy Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain

6. Pharmacy Department, Hospital del Mar, Barcelona, Spain

7. Medicine Department, School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain

Abstract

ABSTRACT Linezolid serum trough ( C min ) and peak ( C max ) levels were determined prospectively in 90 patients. Adequate exposure was defined as a C min of 2 to 8 mg/liter. Therapy was empirical (73.3%) or targeted (26.7%). Wide interindividual variability in linezolid C min levels was recorded (0.1 to 25.2 μg/ml). Overall, 65.5% of the patients had out-of-range, 41.1% had subtherapeutic, and 24.4% had supratherapeutic trough levels. We did not find a correlation between abnormal levels and adverse events, in-hospital mortality, or overall poor outcome.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00687-17

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