Glucan-Chitin Particles Enhance Th17 Response and Improve Protective Efficacy of a Multivalent Antigen (rCpa1) against Pulmonary Coccidioides posadasii Infection-Reference-Cited by-同舟云学术

Glucan-Chitin Particles Enhance Th17 Response and Improve Protective Efficacy of a Multivalent Antigen (rCpa1) against Pulmonary Coccidioides posadasii Infection

Published:2018-11 Issue:11 Volume:86 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Hung Chiung-Yu¹,Zhang Hao¹,Castro-Lopez Natalia¹,Ostroff Gary R.²,Khoshlenar Payam²,Abraham Ambily²,Cole Garry T.¹,Negron Austin¹,Forsthuber Thomas¹,Peng Tao³,Galgiani John N.³,Ampel Neil M.³⁴,Yu Jieh-Juen¹

Affiliation:

1. Department of Biology and South Texas Center for Emerging Infectious Diseases, University of Texas, San Antonio, Texas, USA

2. Program in Molecular Medicine and Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA

3. Valley Fever Center for Excellence, College of Medicine, University of Arizona, Tucson, Arizona, USA

4. Southern Arizona Veterans Affairs Health Care System, Tucson, Arizona, USA

Abstract

Developing an effective and safe recombinant vaccine requires microbe-specific antigens combined with an adjuvant/delivery system to strengthen protective immunity. In this study, we designed and expressed a multivalent recombinant Coccidioides polypeptide antigen (rCpa1) that consists of three previously identified antigens (i.e., Ag2/Pra, Cs-Ag, and Pmp1) and five pathogen-derived peptides with high affinity for human major histocompatibility complex class II (MHC-II) molecules.

Funder

NIAID

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00070-18

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2. 2016 Infectious Diseases Society of America (IDSA) Clinical Practice Guideline for the Treatment of Coccidioidomycosis

3. Pulmonary Coccidioidomycosis