Large-Scale CRISPRi and Transcriptomics of Staphylococcus epidermidis Identify Genetic Factors Implicated in Lifestyle Versatility-Reference-Cited by-同舟云学术

Large-Scale CRISPRi and Transcriptomics of Staphylococcus epidermidis Identify Genetic Factors Implicated in Lifestyle Versatility

Published:2022-12-20 Issue:6 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Spoto Michelle¹²,Riera Puma Johanna P.¹,Fleming Elizabeth¹,Guan Changhui¹,Ondouah Nzutchi Yvette¹,Kim Dean¹,Oh Julia¹^ORCID

Affiliation:

1. The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA

2. The University of Connecticut Health Center, Farmington, Connecticut, USA

Abstract

Staphylococcus epidermidis is a bacteria that broadly inhabits healthy human skin, yet it is also a common cause of skin infections and bloodstream infections associated with implanted medical devices. Because human skin has many different types of S. epidermidis , each containing different genes, our goal is to determine how these different genes allow S. epidermidis to switch from healthy growth in the skin to being an infectious pathogen.

Funder

HHS | National Institutes of Health

National Science Foundation

U.S. Department of Defense

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02632-22

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