Affiliation:
1. Department of Biochemistry and Plant Pathology, College of Agricultural and Life Sciences, University of Wisconsin, Madison, Wisconsin 53706
Abstract
Extracts of pure cultures of
Penicillium roqueforti
isolated from toxic feed samples and of
P. roqueforti
NRRL 849 were lethal to rats by either intraperitoneal or oral administration. Purification studies guided by this test led to the isolation of a major toxin which showed intraperitoneal and oral median lethal dose values in weanling rats of 11 and 115 mg/kg, respectively. Partial characterization of the crystalline compound, C
17
H
20
O
6
, by infrared, ultra violet, PMR, and mass spectroscopy, and by several chemical transformations indicated the presence of three C-methyl substituents plus one acetoxy, one aldehyde, and one α,β-unsaturated ketone group. Two oxygen atoms are present either in epoxide or ether form.
Publisher
American Society for Microbiology
Subject
General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
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