Genome-Wide Assessment of Streptococcus agalactiae Genes Required for Survival in Human Whole Blood and Plasma-Reference-Cited by-同舟云学术

Genome-Wide Assessment of Streptococcus agalactiae Genes Required for Survival in Human Whole Blood and Plasma

Published:2020-09-18 Issue:10 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Zhu Luchang¹^ORCID,Yerramilli Prasanti¹,Pruitt Layne¹,Ojeda Saavedra Matthew¹,Cantu Concepcion C.¹,Olsen Randall J.¹²,Beres Stephen B.¹^ORCID,Waller Andrew S.³,Musser James M.¹²

Affiliation:

1. Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, and Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA

2. Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York, USA

3. Animal Health Trust, Newmarket, Suffolk, United Kingdom

Abstract

Streptococcus agalactiae (group B streptococcus, or GBS) is a common cause of bacteremia and sepsis in newborns, pregnant women, and immunocompromised patients. The molecular mechanisms used by GBS to survive and proliferate in blood are not well understood. Here, using a highly virulent GBS strain and transposon-directed insertion site sequencing (TraDIS), we performed genome-wide screens to discover novel GBS genes required for bacterial survival in human whole blood and plasma.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00357-20

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