Population Pharmacokinetics of the Antimalarial Amodiaquine: a Pooled Analysis To Optimize Dosing

Author:

Ali Ali Mohamed123,Penny Melissa A.12,Smith Thomas A.12,Workman Lesley45,Sasi Philip6,Adjei George O.78,Aweeka Francesca9,Kiechel Jean-René10,Jullien Vincent11,Rijken Marcus J.12,McGready Rose1213,Mwesigwa Julia1415,Kristensen Kim16,Stepniewska Kasia1317,Tarning Joel131718ORCID,Barnes Karen I.45,Denti Paolo4ORCID,

Affiliation:

1. Swiss Tropical and Public Health Institute, Basel, Switzerland

2. University of Basel, Basel, Switzerland

3. Ifakara Health Institute, Bagamoyo, Tanzania

4. Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

5. WorldWide Antimalarial Resistance Network (WWARN) Clinical Pharmacology and Southern African Regional Hub, University of Cape Town, Cape Town, South Africa

6. Muhimbili University of Health and Allied Sciences, Dar-es-Salaam, Tanzania

7. Centre for Tropical Clinical Pharmacology and Therapeutics, College of Health Sciences, University of Ghana, Korle Bu, Ghana

8. Office of Research, Innovation and Development, University of Ghana, Legon, Ghana

9. Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, California, USA

10. Drugs for Neglected Diseases Initiative, Geneva, Switzerland

11. Service de Pharmacologie, Hôpital Européen George Pompidou, Université Paris Descartes, Paris, France

12. Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand

13. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

14. Medical Research Council Unit, Fajara, the Gambia

15. Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium

16. Development DMPK-PKPD, Novo Nordisk, Copenhagen, Denmark

17. Worldwide Antimalarial Resistance Network, University of Oxford, Oxford, United Kingdom

18. Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Abstract

Amodiaquine plus artesunate is the recommended antimalarial treatment in many countries where malaria is endemic. However, pediatric doses are largely based on a linear extrapolation from adult doses.

Funder

Bill and Melinda Gates Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference74 articles.

1. World Health Organization. 2016. World malaria report. World Health Organization, Geneva, Switzerland.

2. World Health Organization. 2015. Status report on artemisinin and ACT resistance, p 1–8. World Health Organization, Geneva, Switzerland.

3. Plasmodium falciparum: multifaceted resistance to artemisinins

4. Genomic epidemiology of artemisinin resistant malaria

5. World Trade Report 2015

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