Sensitivity to Vaccines, Therapeutic Antibodies, and Viral Entry Inhibitors and Advances To Counter the SARS-CoV-2 Omicron Variant

Author:

Zhou Hao12ORCID,Møhlenberg Michelle34,Thakor Jigarji C.5,Tuli Hardeep Singh6,Wang Pengfei7,Assaraf Yehuda G.8,Dhama Kuldeep5,Jiang Shibo9

Affiliation:

1. Department of Microbiology, NYU Grossman School of Medicine, New York, New York, USA

2. College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, China

3. Department of Biomedicine, Aarhus University, Aarhus, Denmark

4. Center for Cancer Biology, Department of Oncology, VIB-KU Leuven, Leuven, Belgium

5. Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India

6. Department of Biotechnology, Maharishi Markandeshwar (Deemed University), Mullana, Ambala, Haryana, India

7. State Key Laboratory of Genetic Engineering, Shanghai Institute of Infectious Disease and Biosecurity, School of Life Sciences, Fudan University, Shanghai, China

8. The Fred Wyszkowski Cancer Research Laboratory, Faculty of Biology, Technion Israel Institute of Technology, Haifa, Israel

9. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, China

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) keeps evolving and mutating into newer variants over time, which gain higher transmissibility, disease severity, and spread in communities at a faster rate, resulting in multiple waves of surge in Coronavirus Disease 2019 (COVID-19) cases. A highly mutated and transmissible SARS-CoV-2 Omicron variant has recently emerged, driving the extremely high peak of infections in almost all continents at an unprecedented speed and scale.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology

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