Lytic and Latent Antigens of the Human Gammaherpesviruses Kaposi's Sarcoma-Associated Herpesvirus and Epstein-Barr Virus Induce T-Cell Responses with Similar Functional Properties and Memory Phenotypes-Reference-Cited by-同舟云学术

Lytic and Latent Antigens of the Human Gammaherpesviruses Kaposi's Sarcoma-Associated Herpesvirus and Epstein-Barr Virus Induce T-Cell Responses with Similar Functional Properties and Memory Phenotypes

Published:2007-05 Issue:9 Volume:81 Page:4904-4908
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Bihl Florian¹,Narayan Murli²,Chisholm John V.¹,Henry Leah M.¹,Suscovich Todd J.¹,Brown Elizabeth E.³,Welzel Tania M.³,Kaufmann Daniel E.¹,Zaman Tauheed M.¹⁴,Dollard Sheila⁵,Martin Jeff N.⁶,Wang Fred²,Scadden David T.⁷,Kaye Kenneth M.²,Brander Christian¹

Affiliation:

1. Partners AIDS Research Center, Massachusetts General Hospital

2. Channing Laboratory, Brigham and Women's Hospital, Boston, Massachusetts

3. Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland

4. Lemuel Shattuck Hospital, Harvard Medical School, Boston, Massachusetts

5. Centers for Disease Control and Prevention, Atlanta, Georgia

6. Department of Epidemiology and Biostatistics, University of California, San Francisco, California

7. Center for Regenerative Medicine and Technology, Massachusetts General Hospital Cancer Center, Harvard Medical School, and Harvard Stem Cell Institute, Boston, Massachusetts

Abstract

ABSTRACT The cellular immunity against Kaposi's sarcoma-associated herpesvirus (KSHV) is poorly characterized and has not been compared to T-cell responses against other human herpesviruses. Here, novel and dominant targets of KSHV-specific cellular immunity are identified and compared to T cells specific for lytic and latent antigens in a second human gammaherpesvirus, Epstein-Barr virus. The data identify a novel HLA-B57- and HLA-B58-restricted epitope in the Orf57 protein and show consistently close parallels in immune phenotypes and functional response patterns between cells targeting lytic or latent KSHV- and EBV-encoded antigens, suggesting common mechanisms in the induction of these responses.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02509-06

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