Antifungal Effect of All- trans Retinoic Acid against Aspergillus fumigatus In Vitro and in a Pulmonary Aspergillosis In Vivo Model-Reference-Cited by-同舟云学术

Antifungal Effect of All- trans Retinoic Acid against Aspergillus fumigatus In Vitro and in a Pulmonary Aspergillosis In Vivo Model

Published:2021-02-17 Issue:3 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Campione Elena¹^ORCID,Gaziano Roberta²,Doldo Elena³,Marino Daniele²,Falconi Mattia⁴,Iacovelli Federico⁴,Tagliaferri Daniela⁵,Pacello Lucrezia⁵,Bianchi Luca¹,Lanna Caterina¹,Aurisicchio Luigi⁵,Centofanti Federica³,Di Francesco Paolo²,Del Principe Ilaria⁶,Del Bufalo Francesca⁷,Locatelli Franco⁷,Pistoia Enrico Salvatore²,Marra Emanuele⁵,Orlandi Augusto³

Affiliation:

1. Dermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy

2. Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy

3. Anatomic Pathology, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

4. Department of Biology, University of Rome Tor Vergata, Rome, Italy

5. Takis S.r.l., Rome, Italy

6. Department of Haematology, University of Rome Tor Vergata, Rome, Italy

7. Department of Haematology, Oncology and Stem Cell Transplantation, Bambino Gesù Children’s Hospital (IRCSS), Rome, Italy

Abstract

Aspergillus fumigatus is the most common opportunistic fungal pathogen and causes invasive pulmonary aspergillosis (IPA), with high mortality among immunosuppressed patients. The fungistatic activity of all- trans retinoic acid (ATRA) has been recently described in vitro .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01874-20

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