Affiliation:
1. Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago 60612, USA.
Abstract
Rhodamine and tetraphenylphosphonium, the substrates of the Bacillus subtilis multidrug efflux transporter Bmr, induce the expression of Bmr through direct interaction with its transcriptional activator BmrR. Here we show that the C-terminal domain of BmrR, expressed individually, binds both these compounds and therefore can be used as a model for molecular analysis of the phenomenon of multidrug recognition.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
36 articles.
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