Molecular Characterization of Isoniazid-Resistant Mycobacterium tuberculosis Clinical Isolates in Lithuania

Author:

Bakonyte Daiva1,Baranauskaite Aurelija1,Cicenaite Jurate2,Sosnovskaja Anaida2,Stakenas Petras1

Affiliation:

1. Laboratory of Immunology, Institute of Biotechnology, Vilnius 2028

2. National Tuberculosis Reference Laboratory, The Republican Hospital of Tuberculosis and Lung Diseases, Vilnius 2040, Lithuania

Abstract

ABSTRACT Mutations at codon 315 of the katG gene were detected in 312 of 364 (85.7%) isoniazid-resistant Mycobacterium tuberculosis isolates. Seven of 52 (13.5%) isoniazid-resistant isolates with the wild-type Ser315 codon and 10 of 52 (19.2%) isoniazid-resistant isolates with a mutated katG allele had mutation −15C→T in the promoter of the mabA-inhA operon.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference19 articles.

1. Abate, G., S. E. Hoffner, V. O. Thomsen, and H. Miorner. 2000. Characterization of isoniazid-resistant strains of Mycobacterium tuberculosis on the basis of phenotypic properties and mutations in katG. Eur. J. Clin. Microbiol. Infect. Dis.20:329-333.

2. Banerjee, A., E. Dubnau, A. Quemard, V. Balasubramian, K. S. Um, T. Wilson, D. Collins, G. de Lisle, and W. R. Jacobs, Jr. 1994. inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis. Science263:227-230.

3. EuroTB and the National Coordinators for Tuberculosis Surveillance in the World Health Organization European Region. 2002. Surveillance of tuberculosis in Europe. Report of tuberculosis cases notified in 1999 March 2002. EuroTB-InVS Saint-Maurice France.

4. Characterization of the katG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis

5. Kent P. T. and G. P. Kubica. 1985. Public health mycobacteriology. A guide for the level III laboratory. Centers for Disease Control U.S. Department of Health and Human Services Atlanta Ga.

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