Affiliation:
1. Department of Microbiology, University of Oklahoma School of Medicine, Oklahoma City, Oklahoma 73104
Abstract
Seven nonencapsulated mutants of
Cryptococcus neoformans
were isolated from an encapsulated strain of human origin. Initially, the mutants were avirulent for mice. After several months of subculturing, six of the seven isolates reverted to the encapsulated state and possessed varying degrees of virulence. The results of these experiments suggest that a strong correlation exists between the presence of a capsule and the virulence of
C. neoformans
.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
138 articles.
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