Immediate Interferon Gamma Induction Determines Murine Host Compatibility Differences between Toxoplasma gondii and Neospora caninum-Reference-Cited by-同舟云学术

Immediate Interferon Gamma Induction Determines Murine Host Compatibility Differences between Toxoplasma gondii and Neospora caninum

Published:2020-03-23 Issue:4 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Coombs Rachel S.¹^ORCID,Blank Matthew L.¹,English Elizabeth D.¹^ORCID,Adomako-Ankomah Yaw¹,Urama Ifeanyi-Chukwu Samuel¹,Martin Andrew T.²,Yarovinsky Felix²,Boyle Jon P.¹

Affiliation:

1. Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

2. Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA

Abstract

Rodents are critical for the transmission of Toxoplasma gondii to the definitive feline host via predation, and this relationship has been extensively studied as a model for immune responses to parasites. Neospora caninum is a closely related coccidian parasite of ruminants and canines but is not naturally transmitted by rodents. We compared mouse innate immune responses to N. caninum and T. gondii and found marked differences in cytokine levels and parasite growth kinetics during the first 24 h postinfection (hpi).

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00027-20

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