Mycoplasma pneumoniae Compared to Streptococcus pneumoniae Avoids Induction of Proinflammatory Epithelial Cell Responses despite Robustly Inducing TLR2 Signaling-Reference-Cited by-同舟云学术

Mycoplasma pneumoniae Compared to Streptococcus pneumoniae Avoids Induction of Proinflammatory Epithelial Cell Responses despite Robustly Inducing TLR2 Signaling

Published:2022-08-18 Issue:8 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

de Groot R. C. A.¹^ORCID,Zhu H.¹,Hoogenboezem T.¹,de Bruijn A. C. J. M.¹,Eenjes E.²,’t Jong A. E. J.³,Belo A. I.¹,Estevão S. C.¹,Bajramovic J. J.³,Rottier R. J.²,Kool M.⁴,van Rossum A. M. C.⁵,Unger W. W. J.¹

Affiliation:

1. Laboratory of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, Erasmus MC University Medical Center Rotterdam–Sophia Children’s Hospital, Rotterdam, The Netherlands

2. Department of Pediatric Surgery and Department of Cell Biology, Erasmus MC University Medical Center Rotterdam–Sophia Children’s Hospital, Rotterdam, The Netherlands

3. Alternatives Unit, Biomedical Primate Research Centre, Rijswijk, The Netherlands

4. Department of Pulmonary Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands

5. Department of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, Erasmus MC University Medical Center Rotterdam–Sophia Children’s Hospital, Rotterdam, The Netherlands

Abstract

Mycoplasma pneumoniaeandStreptococcus pneumoniaeare the most common bacterial causes of pneumonia in children. The clinical characteristics of pneumonia differ significantly between the two bacteria. We aimed to elucidate the differences in pathogenesis betweenM. pneumoniaeandS. pneumoniaeby characterizing the respiratory epithelial cell immune response to both pathogens.

Funder

Sophia Scientific Research Foundation

Coolsingel Foundation

Chinese Scholarships Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00129-22

Reference50 articles.

1. World Health Organization. 2016. Pneumonia fact sheet. World Health Organization Geneva Switzerland. Accessed 16 April 2018.