Affiliation:
1. Servicio de Microbiología Clínica, Hospital Clínico San Carlos, Madrid, Spain
Abstract
ABSTRACT
The
in vitro
activity of TR-700 (torezolid) was evaluated against a collection of 660 staphylococcal blood isolates. TR-700 showed excellent activity against all the staphylococci tested. The MIC
50
and MIC
90
values of TR-700, linezolid, daptomycin, and vancomycin against methicillin-resistant
Staphylococcus aureus
(MRSA) isolates were 0.25 and 0.5, 2 and 4, 0.5 and 0.5, and 1 and 2 μg/ml, respectively. TR-700 demonstrated greater
in vitro
potency than linezolid against staphylococci, including linezolid-resistant and vancomycin-nonsusceptible strains, and was 32-fold more active than linezolid against the seven
cfr
-positive MRSA strains tested.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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