Identification of Biased Amino Acid Substitution Patterns in Human Immunodeficiency Virus Type 1 Isolates from Patients Treated with Protease Inhibitors-Reference-Cited by-同舟云学术

Identification of Biased Amino Acid Substitution Patterns in Human Immunodeficiency Virus Type 1 Isolates from Patients Treated with Protease Inhibitors

Published:1999-07 Issue:7 Volume:73 Page:6197-6202
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Shafer Robert W.¹,Hsu Phillip²,Patick Amy K.³,Craig Charles⁴,Brendel Volker⁵

Affiliation:

1. Division of Infectious Diseases, Stanford University Medical Center,1 and

2. Stanford University,2 Stanford, California 94305;

3. Agouron Pharmaceuticals, Inc., San Diego, California 921213;

4. Roche Discovery Welwyn, Welwyn Garden City, Hertsfordshire, United Kingdom4

5. Department of Zoology and Genetics, Iowa State University, Ames, Iowa 50011-32605; and

Abstract

ABSTRACT Human immunodeficiency virus type 1 (HIV-1) amino acid substitutions observed during antiretroviral drug therapy may be caused by drug selection, non-drug-related evolution, or sampling error introduced by the sequencing process. We analyzed HIV-1 sequences from 371 untreated patients and from 178 patients receiving a single protease inhibitor. Amino acid substitution patterns during treatment were compared with inferred substitution patterns arising evolutionarily without treatment. Our results suggest that most treatment-associated amino acid substitutions are caused by selective drug pressure, including substitutions not previously associated with drug resistance.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.73.7.6197-6202.1999

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