The P681H Mutation in the Spike Glycoprotein of the Alpha Variant of SARS-CoV-2 Escapes IFITM Restriction and Is Necessary for Type I Interferon Resistance-Reference-Cited by-同舟云学术

The P681H Mutation in the Spike Glycoprotein of the Alpha Variant of SARS-CoV-2 Escapes IFITM Restriction and Is Necessary for Type I Interferon Resistance

Published:2022-12-14 Issue:23 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Lista Maria Jose¹²,Winstone Helena¹²,Wilson Harry D.¹²^ORCID,Dyer Adam¹²,Pickering Suzanne¹²,Galao Rui Pedro¹²,De Lorenzo Giuditta³^ORCID,Cowton Vanessa M.³,Furnon Wilhelm³,Suarez Nicolas³,Orton Richard³,Palmarini Massimo³²,Patel Arvind H.³²^ORCID,Snell Luke⁴^ORCID,Nebbia Gaia⁴,Swanson Chad¹^ORCID,Neil Stuart J. D.¹²^ORCID

Affiliation:

1. Department of Infectious Diseases, King’s College London, London, United Kingdom

2. UKRI Genotype-2-Phenotype Consortium, London, United Kingdom

3. MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom

4. Centre for Clinical Infection and Diagnostics Research, Department of Infectious Diseases, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom

Abstract

Accumulating evidence suggests that variants of concern (VOC) of SARS-CoV-2 evolve to evade the human immune response, with much interest focused on mutations in the spike protein that escape from antibodies. However, resistance to the innate immune response is essential for efficient viral replication and transmission.

Funder

UKRI | Medical Research Council

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01250-22

Reference67 articles.

1. A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

2. The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets