Ebolavirus Glycoprotein GP Masks both Its Own Epitopes and the Presence of Cellular Surface Proteins-Reference-Cited by-同舟云学术

Ebolavirus Glycoprotein GP Masks both Its Own Epitopes and the Presence of Cellular Surface Proteins

Published:2009-09-15 Issue:18 Volume:83 Page:9596-9601
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Reynard Olivier¹,Borowiak Malgorzata¹,Volchkova Valentina A.¹,Delpeut Sebastien¹,Mateo Mathieu¹,Volchkov Viktor E.¹

Affiliation:

1. INSERM, U758, Laboratoire des Filovirus, Lyon F-69007, France; Université de Lyon, Lyon, F-69007, France; and Université Lyon 1, Lyon F-69007, France; and IFR 128 BioSciences Gerland-Lyon Sud, Lyon F-69007, France

Abstract

ABSTRACT Ebolavirus (EBOV) is the etiological agent of a severe hemorrhagic fever with a high mortality rate. The spike glycoprotein (GP) is believed to be one of the major determinants of virus pathogenicity. In this study, we demonstrated the molecular mechanism responsible for the downregulation of surface markers caused by EBOV GP expression. We showed that expression of mature GP on the plasma membrane results in the masking of cellular surface proteins, including major histocompatibility complex class I. Overexpression of GP also results in the masking of certain antigenic epitopes on GP itself, causing an illusory effect of disappearance from the plasma membrane.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00784-09

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