FUBP3 Degrades the Porcine Epidemic Diarrhea Virus Nucleocapsid Protein and Induces the Production of Type I Interferon

Author:

Dong Sujie12,Kong Ning13,Wang Chunmei13,Li Youwen2,Sun Dage1,Qin Wenzhen1,Zhai Huanjie1,Zhai Xueying1,Yang Xinyu1,Ye Chenqian1,Ye Manqing1,Liu Changlong13,Yu Lingxue13,Zheng Hao13,Tong Wu13,Yu Hai13,Zhang Wen4,Tong Guangzhi13,Shan Tongling13ORCID

Affiliation:

1. Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China

2. College of Animal Science, Tarim University, Xinjiang, China

3. Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonose, Yangzhou University, Yangzhou, China

4. School of Medicine, Jiangsu University, Zhenjiang, China

Abstract

PEDV refers to the alphacoronavirus that is found globally and has re-emerged recently, causing severe financial losses. In PEDV infection, the host activates various host restriction factors to maintain innate antiviral responses to suppress virus replication.

Funder

National Key Resarch and Development Programs of China

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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