Antimicrobial Susceptibility and Molecular Characterization Using Whole-Genome Sequencing of Clostridioides difficile Collected in 82 Hospitals in Japan between 2014 and 2016-Reference-Cited by-同舟云学术

Antimicrobial Susceptibility and Molecular Characterization Using Whole-Genome Sequencing of Clostridioides difficile Collected in 82 Hospitals in Japan between 2014 and 2016

Published:2019-12 Issue:12 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Aoki Kotaro¹^ORCID,Takeda Shinobu²,Miki Takashi³,Ishii Yoshikazu¹,Tateda Kazuhiro¹

Affiliation:

1. Department of Microbiology and Infectious Diseases, Toho University School of Medicine, Tokyo, Japan

2. Drug Discovery Research, Astellas Pharma, Inc., Tokyo, Japan

3. Japan Astellas Pharma, Inc., Tokyo, Japan

Abstract

We studied the antimicrobial susceptibility and molecular characteristics, using draft whole-genome sequencing, of Clostridioides ( Clostridium ) difficile strains before and after treatment in adults with C. difficile infection (CDI) enrolled in a phase III, randomized, nationwide study of fidaxomicin versus vancomycin in Japan (ClinicalTrials.gov identifier NCT02179658). C. difficile strains were cultured from stool samples collected before and after standard treatment with either fidaxomicin or vancomycin.

Funder

Astellas Pharma

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01259-19

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