Erythromycin bioactivity is stable in ophthalmic ointment used for prophylaxis of neonatal gonococcal conjunctivitis

Author:

Bialer M G,Baron E J,Harper R G

Abstract

Erythromycin ophthalmic ointment (E. Fougera & Co., Melville, N.Y.) and erythromycin gluceptate standards prepared in ointment base were stored at room temperature and heated at temperatures up to 45 degrees C for as long as 6 h before being assayed for bioactivity. We were unable to detect any significant loss of antibiotic bioactivity.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference20 articles.

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2. Prophylaxis of neonatal conjunctivitis, an analytic review;Bernstein G. A.;Clin. Pediatr.,1982

3. Unit dose erythromycin ophthalmic ointment for neonatal ocular prophylaxis;Bryant B. G.;JOGN Nurs.,1984

4. Neonatal gonococcal ophthalmia-California;Centers for Disease Control.;Morbid. Mortal. Weekly Rep.,1983

5. Gonococcal conjunctivitis in a four-month-old infant;Fivush B.;Sex. Transm. Dis.,1980

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