Genomic Characterization of Enterobacter cloacae Isolates from China That Coproduce KPC-3 and NDM-1 Carbapenemases-Reference-Cited by-同舟云学术

Genomic Characterization of Enterobacter cloacae Isolates from China That Coproduce KPC-3 and NDM-1 Carbapenemases

Published:2016-04 Issue:4 Volume:60 Page:2519-2523
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Du Hong¹²,Chen Liang²,Chavda Kalyan D.²,Pandey Ruchi²,Zhang Haifang¹,Xie Xiaofang¹,Tang Yi-Wei³^ORCID,Kreiswirth Barry N.²

Affiliation:

1. Department of Clinical Laboratory, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People's Republic of China

2. Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA

3. Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

Abstract

ABSTRACT Here, we report two Enterobacter cloacae sequence type 231 isolates coproducing KPC-3 and NDM-1 that have caused lethal infections in a tertiary hospital in China. The bla NDM-1 -harboring plasmids carry IncA/C 2 and IncR replicons, showing a mosaic plasmid structure, and the bla NDM-1 is harbored on a novel class I integron-like element. bla KPC-3 is located on a Tn 3 -Δ bla TEM-1 - bla KPC-3 -ΔTn 1722 element, flanked by two 9-bp direct-repeat sequences and harbored on an IncX6 plasmid.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.03053-15

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