Sources of rats free of latent Pneumocystis carinii

Author:

Bartlett M S1,Durkin M M1,Jay M A1,Queener S F1,Smith J W1

Affiliation:

1. Department of Pathology, Indiana University School of Medicine, Indianapolis 46223.

Abstract

Two sources of rats free of latent Pneumocystis carinii are described. First, rats from a virus-free colony failed to develop infection after 8 weeks of immune suppression unless they were housed with previously infected rats. Second, pregnant rats (non-virus free) received trimethoprim-sulfamethoxazole from day 10 of gestation until the pups were weaned. Pups raised in filter-topped cages and immunosuppressed for 8 weeks were free of P. carinii infection.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference5 articles.

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2. Pneumocystis in rats, relapse and chemotherapy;Frenkel J. K.;Lab. Invest.,1966

3. Pifer L. L. C. P. Lattuada C. C. Edwards D. R. Woods and D. R. Owens. 1984. Pneumocystis carinii infection in germn-free NOTES 1795

4. Absence of Pneumocystis carinii in Lobund germfree and conventional rat colonies;Wagner M.;Prog. Clin. Biol. Res.,1985

5. Spontaneous wasting disease in nude mice associated with Pneumocystis carinii infection;Weir C.;Lab. Anim. Sci.,1986

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