Regulation of the Mitochondrion-Fatty Acid Axis for the Metabolic Reprogramming of Chlamydia trachomatis during Treatment with β-Lactam Antimicrobials-Reference-Cited by-同舟云学术

Regulation of the Mitochondrion-Fatty Acid Axis for the Metabolic Reprogramming of Chlamydia trachomatis during Treatment with β-Lactam Antimicrobials

Published:2021-04-27 Issue:2 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Shima Kensuke¹^ORCID,Kaufhold Inga¹,Eder Thomas²³,Käding Nadja¹,Schmidt Nis¹,Ogunsulire Iretiolu M.¹,Deenen René⁴,Köhrer Karl⁴,Friedrich Dirk¹^ORCID,Isay Sophie E.¹,Grebien Florian³,Klinger Matthias⁵,Richer Barbara C.⁶,Günther Ulrich L.⁶,Deepe George S.⁷,Rattei Thomas²,Rupp Jan¹⁸^ORCID

Affiliation:

1. Department of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany

2. Division of Computational Systems Biology, University Vienna, Vienna, Austria

3. Institute for Medical Biochemistry, University of Veterinary Medicine Vienna, Vienna, Austria

4. Biological and Medical Research Center (BMFZ), Heinrich Heine University Düsseldorf, Düsseldorf, Germany

5. Institute of Anatomy, University of Lübeck, Lübeck, Germany

6. Institute of Chemistry and Metabolomics, University of Lübeck, Lübeck, Germany

7. Division of Infectious Diseases, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA

8. German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Lübeck, Germany

Abstract

The mitochondrion generates most of the ATP in eukaryotic cells, and its activity is used for controlling the intracellular growth of Chlamydia trachomatis . Furthermore, mitochondrial activity is tightly connected to host fatty acid synthesis that is indispensable for chlamydial membrane biogenesis.

Funder

The German Research Foundation

The DFG-funded international research training group (IRTG) 1911

ERA_NET PathoGenoMics

The University of Luebeck

German Center for Infection Research

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00023-21