Characterization of SARS-CoV-2 Variants B.1.617.1 (Kappa), B.1.617.2 (Delta), and B.1.618 by Cell Entry and Immune Evasion-Reference-Cited by-同舟云学术

Characterization of SARS-CoV-2 Variants B.1.617.1 (Kappa), B.1.617.2 (Delta), and B.1.618 by Cell Entry and Immune Evasion

Published:2022-04-26 Issue:2 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Ren Wenlin¹,Ju Xiaohui¹,Gong Mingli¹,Lan Jun²,Yu Yanying¹,Long Quanxin³^ORCID,Kenney Devin J.⁴⁵,O’Connell Aoife K.⁴⁵,Zhang Yu¹,Zhong Jin⁶^ORCID,Zhong Guocai⁷⁸^ORCID,Douam Florian⁴⁵,Wang Xinquan²,Huang Ailong³,Zhang Rong⁹,Ding Qiang¹^ORCID

Affiliation:

1. Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing, China

2. School of Life Sciences, Tsinghua University, Beijing, China

3. Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, China

4. Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, USA

5. National Emerging Infectious Diseases Laboratories, Boston University, Boston, Massachusetts, USA

6. Unit of Viral Hepatitis, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China

7. Shenzhen Bay Laboratory, Shenzhen, China

8. School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China

9. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Biosafety Level 3 Laboratory, Fudan University, Shanghai, China

Abstract

SARS-CoV-2, the causative agent of pandemic COVID-19, is rapidly evolving to be more transmissible and to exhibit evasive immune properties, compromising neutralization by antibodies from vaccinated individuals or convalescent-phase sera. Recently, SARS-CoV-2 variants B.1.617.1 (Kappa), B.1.617.2 (Delta), and B.1.618 with mutations within the spike proteins were identified in India.

Funder

Beijing Municipal Natural Science Foundation

Start-up Foundation of Tsinghua University

Tsinghua University Spring Breeze Fund

Advanced Customer Cultivation Project of Wuhan National Biosafety Laboratory, CAS

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00099-22